Toxic Avenger discovers that his blind girlfriend, Claire, could regain her sight through a costly operation. To finance it, he takes a job as a spokesperson for Apocalypse Inc., unaware that he is inadvertently aiding the return of evil to Tromaville. He doesn't even realize he has transformed into a yuppie! However, when Claire reveals to him how he has lost his sanity and shows the corruption he has caused, Toxie also realizes that his new boss is the devil himself. It's time to fight against the forces of evil and massacre as many as possible!