Melvin is cleaning at the local gym when he falls victim to a malicious prank by local bullies. He is thrown out of a third-floor window and lands in a barrel of radioactive waste. Instead of melting to death, Melvin absorbs the deadly chemicals and transforms into THE TOXIC AVENGER – a righteous mutant who battles his former tormentors, as well as the many villains and corrupt politicians of Tromaville. No evildoer is safe when Toxie goes on the attack, crushing heads in the process.